{"product_id":"reed-biotech-sarm1-polyclonal-antibody-ra34730","title":"SARM1 Polyclonal Antibody","description":"\u003cp\u003ecaution:Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.,function:Involved in innate immnune response. Acts as a negative regulator of TICAM1\/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1\/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.,similarity:Contains 1 TIR domain.,similarity:Contains 2 SAM (sterile alpha motif) domains.,subunit:Interacts with TICAM1\/TRIF and thereby interferes with TICAM1\/TRIF function.,tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.,\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57251046162772,"sku":"ABM5039124-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57251046195540,"sku":"ABM5039124-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_39d8983f-1af1-4d15-89d1-e84b946d9ebc.webp?v=1790235137","url":"https:\/\/www.abmium.com\/products\/reed-biotech-sarm1-polyclonal-antibody-ra34730","provider":"ABMIUM","version":"1.0","type":"link"}