{"product_id":"reed-biotech-pdk1-polyclonal-antibody-ra28641","title":"PDK1 Polyclonal Antibody","description":"\u003cp\u003ecatalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates and activates not only PKB\/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM:Phosphorylated on tyrosine and serine\/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser\/Thr protein kinase family. PDK1 subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.,subunit:Interacts with TUSC4.,tissue specificity:Appears to be expressed ubiquitously.,\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250322940244,"sku":"ABM5033035-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250322973012,"sku":"ABM5033035-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_88041d99-f74f-4792-94cb-8de657febc6c.webp?v=1790234857","url":"https:\/\/www.abmium.com\/products\/reed-biotech-pdk1-polyclonal-antibody-ra28641","provider":"ABMIUM","version":"1.0","type":"link"}