{"product_id":"reed-biotech-mysm1-polyclonal-antibody-ra27551","title":"MYSM1 Polyclonal Antibody","description":"\u003cp\u003ecatalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.,function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase M67A family. MYSM1 subfamily.,similarity:Contains 1 MPN (JAB\/Mov34) domain.,similarity:Contains 1 SANT domain.,similarity:Contains 1 SWIRM domain.,subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11\/TRIP5. Binds histones.,\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250524627284,"sku":"ABM5031945-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250524660052,"sku":"ABM5031945-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody_1_240962b5-c219-42e7-b7a5-88e73ca18691.webp?v=1790234569","url":"https:\/\/www.abmium.com\/products\/reed-biotech-mysm1-polyclonal-antibody-ra27551","provider":"ABMIUM","version":"1.0","type":"link"}