{"product_id":"reed-biotech-lats1-2-phospho-thr1079-1041-polyclonal-antibody-ra21132","title":"LATS1\/2 (phospho Thr1079\/1041) Polyclonal Antibody","description":"\u003cp\u003elarge tumor suppressor kinase 1(LATS1) Homo sapiens The protein encoded by this gene is a putative serine\/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2\/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57248200917332,"sku":"ABM5025526-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57248200950100,"sku":"ABM5025526-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody.webp?v=1790791467","url":"https:\/\/www.abmium.com\/products\/reed-biotech-lats1-2-phospho-thr1079-1041-polyclonal-antibody-ra21132","provider":"ABMIUM","version":"1.0","type":"link"}