{"product_id":"reed-biotech-e2a-phospho-thr355-polyclonal-antibody-ra24382","title":"E2A (phospho Thr355) Polyclonal Antibody","description":"\u003cp\u003etranscription factor 3(TCF3) Homo sapiens This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have bee\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57250288861524,"sku":"ABM5028776-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57250288894292,"sku":"ABM5028776-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody.webp?v=1790791467","url":"https:\/\/www.abmium.com\/products\/reed-biotech-e2a-phospho-thr355-polyclonal-antibody-ra24382","provider":"ABMIUM","version":"1.0","type":"link"}