{"product_id":"reed-biotech-cxxc4-rabbit-polyclonal-antibody-ra23913","title":"CXXC4 Rabbit Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless\/integrated signaling pathway. The encoded protein negatively regulates wingless\/integrated signaling through interaction with the post synaptic density protein\/ Drosophila disc large tumor suppressor\/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],\u003c\/p\u003e","brand":"Reed Biotech","offers":[{"title":"50 µL","offer_id":57251035185492,"sku":"ABM5028307-1","price":113.4,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":57251035218260,"sku":"ABM5028307-2","price":153.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/Antibody.webp?v=1790791467","url":"https:\/\/www.abmium.com\/products\/reed-biotech-cxxc4-rabbit-polyclonal-antibody-ra23913","provider":"ABMIUM","version":"1.0","type":"link"}