{"product_id":"rabbit-polyclonal-antibody-to-ubqln4-p52199","title":"Anti-UBQLN4 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eUBQLN4\u003c\/strong\u003e regulates protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. UBQLN4 acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain. UBQLN4 is a key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58168994267476,"sku":"ABM421269-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58168994300244,"sku":"ABM421269-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58168994333012,"sku":"ABM421269-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-ubqln4-p52199","provider":"ABMIUM","version":"1.0","type":"link"}