{"product_id":"rabbit-polyclonal-antibody-to-trem2-p23587","title":"Anti-TREM2 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eTREM2\u003c\/strong\u003e forms a receptor signalling complex with TYROBP which mediates signalling and cell activation following ligand binding. TREM2 acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58031189197140,"sku":"ABM413276-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58031189229908,"sku":"ABM413276-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58031189262676,"sku":"ABM413276-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-trem2-p23587","provider":"ABMIUM","version":"1.0","type":"link"}