{"product_id":"rabbit-polyclonal-antibody-to-tmem100-p30991","title":"Anti-TMEM100 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eTMEM100\u003c\/strong\u003e plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signalling pathway upon stimulation by bone morphogenetic proteins, such as GDF2\/BMP9 and BMP10. TMEM100 is involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58031402582356,"sku":"ABM414207-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58031402615124,"sku":"ABM414207-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58031402647892,"sku":"ABM414207-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-tmem100-p30991","provider":"ABMIUM","version":"1.0","type":"link"}