{"product_id":"rabbit-polyclonal-antibody-to-rrp8-p10170","title":"Anti-RRP8 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eRRP8\u003c\/strong\u003e is essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)\/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58007072211284,"sku":"ABM405388-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58007072244052,"sku":"ABM405388-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58007072276820,"sku":"ABM405388-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-rrp8-p10170","provider":"ABMIUM","version":"1.0","type":"link"}