{"product_id":"rabbit-polyclonal-antibody-to-rnf4-p34567","title":"Anti-RNF4 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eRNF4\u003c\/strong\u003e is an E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. RNF4 regulates the degradation of several proteins including PML and the transcriptional activator PEA3. RNF4 is involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58161264984404,"sku":"ABM417354-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58161265017172,"sku":"ABM417354-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58161265049940,"sku":"ABM417354-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-rnf4-p34567","provider":"ABMIUM","version":"1.0","type":"link"}