{"product_id":"rabbit-polyclonal-antibody-to-rnf135-c-term-p33789","title":"Anti-RNF135(C-term) Rabbit Polyclonal Antibody","description":"\u003cp\u003eE2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response. Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyses the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signalling pathway. Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signalling pathway.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58157157777748,"sku":"ABM416661-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58157157810516,"sku":"ABM416661-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58157157843284,"sku":"ABM416661-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-rnf135-c-term-p33789","provider":"ABMIUM","version":"1.0","type":"link"}