{"product_id":"rabbit-polyclonal-antibody-to-pkr-ab-446-p41464","title":"Anti-PKR(Ab-446) Rabbit Polyclonal Antibody","description":"\u003cp\u003eIFN-induced dsRNA-dependent serine\/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1\/eIF-2-alpha) and plays a key role in the innate immune response to viral infection. EIF2AK2 inhibits viral replication via the integrated stress response (ISR): EIF2S1\/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1\/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58162409275732,"sku":"ABM418666-1","price":210.0,"currency_code":"USD","in_stock":true},{"title":"100 µL","offer_id":58162409308500,"sku":"ABM418666-2","price":300.0,"currency_code":"USD","in_stock":true},{"title":"1 mL","offer_id":58162409341268,"sku":"ABM418666-3","price":2237.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-pkr-ab-446-p41464","provider":"ABMIUM","version":"1.0","type":"link"}