{"product_id":"rabbit-polyclonal-antibody-to-gper-p34773","title":"Anti-GPER Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eGPER\u003c\/strong\u003e1 is a G protein-coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signalling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signalling pathways such as PI3K\/Akt and ERK\/MAPK. GPER1 mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58161335632212,"sku":"ABM417530-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58161335664980,"sku":"ABM417530-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58161335697748,"sku":"ABM417530-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-gper-p34773","provider":"ABMIUM","version":"1.0","type":"link"}