{"product_id":"rabbit-polyclonal-antibody-to-fbxo11-n-term-p31715","title":"Anti-FBXO11 (N-term) Rabbit Polyclonal Antibody","description":"\u003cp\u003eSubstrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL\/CDT2, BCL6, SNAI1 and PRDM1\/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signalling, cell migration and the timing of the cell-cycle progression and exit.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58035447234900,"sku":"ABM414883-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58035447267668,"sku":"ABM414883-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58035447300436,"sku":"ABM414883-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-fbxo11-n-term-p31715","provider":"ABMIUM","version":"1.0","type":"link"}