{"product_id":"rabbit-polyclonal-antibody-to-ercc8-p30880","title":"Anti-ERCC8 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eERCC8\u003c\/strong\u003e is a substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes. Following recruitment to lesion-stalled RNA polymerase II (Pol II), the CSA complex mediates ubiquitination of Pol II subunit POLR2A\/RPB1 at 'Lys-1268', a critical TC-NER checkpoint, governing RNA Pol II stability and initiating DNA damage excision by TFIIH recruitment.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58031387443540,"sku":"ABM414104-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58031387476308,"sku":"ABM414104-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58031387509076,"sku":"ABM414104-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-ercc8-p30880","provider":"ABMIUM","version":"1.0","type":"link"}