{"product_id":"rabbit-polyclonal-antibody-to-arrb2-p33410","title":"Anti-ARRB2 Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eARRB2\u003c\/strong\u003e functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signalling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58157090701652,"sku":"ABM416302-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58157090734420,"sku":"ABM416302-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58157090767188,"sku":"ABM416302-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-polyclonal-antibody-to-arrb2-p33410","provider":"ABMIUM","version":"1.0","type":"link"}