{"product_id":"rabbit-monoclonal-antibody-to-raf-1-50885","title":"Anti-Raf-1 Rabbit Monoclonal Antibody","description":"\u003cp\u003e\u003cstrong\u003eRAF1\u003c\/strong\u003e is a serine\/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK\/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1\/MEK1 and MAP2K2\/MEK2) and the extracellular signal-regulated kinases (MAPK3\/ERK1 and MAPK1\/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD\/Bcl2-antagonist of cell death at 'Ser-75'.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58006345843028,"sku":"ABM400646-1","price":210.0,"currency_code":"USD","in_stock":true},{"title":"100 µL","offer_id":58006345875796,"sku":"ABM400646-2","price":300.0,"currency_code":"USD","in_stock":true},{"title":"1 mL","offer_id":58006345908564,"sku":"ABM400646-3","price":2237.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-monoclonal-antibody-to-raf-1-50885","provider":"ABMIUM","version":"1.0","type":"link"}