{"product_id":"rabbit-monoclonal-antibody-to-erbb-3-50833","title":"Anti-ErbB-3 Rabbit Monoclonal Antibody","description":"\u003cp\u003eTyrosine kinase receptor that, despite substitutions of key catalytic residues in the kinase domain, retains residual catalytic activity enabling autophosphorylation. ERBB3 functions primarily as a heterodimer, preferentially partnering with ERBB2\/HER2, which phosphorylates ERBB3 on specific tyrosine residues and provides the kinase activity required for downstream signalling. ERBB3 binds neuregulins NRG1 and NRG2 through its extracellular domain, which induces conformational change from a tethered autoinhibited state to an extended conformation competent for dimerization.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor research use only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Promab","offers":[{"title":"50 µL","offer_id":58006337913172,"sku":"ABM400594-1","price":174.2,"currency_code":"GBP","in_stock":true},{"title":"100 µL","offer_id":58006337945940,"sku":"ABM400594-2","price":249.55,"currency_code":"GBP","in_stock":true},{"title":"1 mL","offer_id":58006337978708,"sku":"ABM400594-3","price":1863.52,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/rabbit-monoclonal-antibody-to-erbb-3-50833","provider":"ABMIUM","version":"1.0","type":"link"}