{"product_id":"proteogenix-siltuximab-biosimilar-anti-il6-mab-research-grade","title":"Siltuximab Biosimilar – Anti-IL6 mAb – Research Grade","description":"\u003ch2\u003eGeneral Information on Siltuximab Anti-IL6 Monoclonal Antibody\u003c\/h2\u003e \u003cp\u003eThe Siltuximab antibody is a chimeric mouse\/human monoclonal antibody designed to bind human interleukin-6 (IL-6), a soluble glycoprotein involved in pro-inflammatory signaling pathways.\u003c\/p\u003e \u003cp\u003eSiltuximab is widely studied in research involving cytokine signaling, immune response regulation and inflammatory mechanisms. IL-6 is one of the major pro-inflammatory cytokines overexpressed in multiple pathological conditions and is produced by several cell types including T cells, B cells, monocytes, fibroblasts and endothelial cells.\u003c\/p\u003e \u003cp\u003eBy interacting with membrane-bound or soluble IL-6 receptors (IL6R), IL-6 can trigger multiple biological responses such as B-cell proliferation, vascular endothelial growth factor (VEGF) production and immune system dysregulation.\u003c\/p\u003e \u003cp\u003eSiltuximab has been investigated in research related to inflammatory diseases, oncology and cytokine-mediated pathways, including studies involving multicentric Castleman disease (MCD), multiple myeloma and immune response dysregulation\u003c\/p\u003e \u003ch2\u003eApplications\u003c\/h2\u003e \u003cp\u003eThis anti-IL6 monoclonal antibody is suitable for:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ecytokine signaling studies\u003c\/li\u003e \u003cli\u003eELISA and binding assays\u003c\/li\u003e \u003cli\u003eantibody characterization\u003c\/li\u003e \u003cli\u003eimmunology research\u003c\/li\u003e \u003cli\u003einflammation-related studies\u003c\/li\u003e \u003cli\u003ecell-based assays\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003cstrong\u003eThis Siltuximab biosimilar anti-IL6 monoclonal antibody is intended for research use only.\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number PX-TA1029.\u003c\/p\u003e\u003cp\u003eTarget: Siltuximab Biosimilar – Anti-IL6 mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: Mammalian cells; Purity: \u0026gt;85%; Molecular weight: 145kDa; Buffer: PBS pH7.5; Applications: ELISA, WB.\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/PX-TA1029.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/msds\/MSDS_PX-TA1029.pdf\"\u003eDownload the manufacturer safety data sheet (MSDS\/SDS)\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57357921222996,"sku":"ABM135004-1","price":130.0,"currency_code":"USD","in_stock":true},{"title":"100ug","offer_id":57357921255764,"sku":"ABM135004-2","price":197.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":57357921288532,"sku":"ABM135004-3","price":399.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/sds-validation-siltuximab-biosimilar-anti-il6-mab-research-grade_a6ef60e3-04fe-4549-a3f2-223a9262ac9e.png?v=1790891348","url":"https:\/\/www.abmium.com\/products\/proteogenix-siltuximab-biosimilar-anti-il6-mab-research-grade","provider":"ABMIUM","version":"1.0","type":"link"}