{"product_id":"proteogenix-recombinant-mouse-chit1-protein-n-his","title":"Recombinant Mouse CHIT1 Protein, N-His","description":"\u003ch2\u003eIntroduction to Recombinant Mouse CHIT1 Protein\u003c\/h2\u003e \u003cp\u003eRecombinant Mouse CHIT1 Protein, also known as chitotriosidase 1, is a glycosyl hydrolase enzyme that is involved in the breakdown of chitin, a major component of fungal cell walls. This protein is encoded by the CHIT1 gene and is highly conserved among mammals, with a 98% similarity to its human counterpart.\u003c\/p\u003e \u003ch2\u003eStructure of Recombinant Mouse CHIT1 Protein\u003c\/h2\u003e \u003cp\u003eThe recombinant mouse CHIT1 protein is composed of 456 amino acids and has a molecular weight of approximately 50 kDa. It is a member of the chitinase family of enzymes and contains a conserved catalytic domain that is responsible for its enzymatic activity.\u003c\/p\u003e \u003cp\u003eThe crystal structure of the recombinant mouse CHIT1 protein has been determined, revealing a three-dimensional structure with a central beta-barrel surrounded by alpha-helices. This structure is similar to other chitinases and is essential for its enzymatic function.\u003c\/p\u003e \u003ch2\u003eActivity of Recombinant Mouse CHIT1 Protein\u003c\/h2\u003e \u003cp\u003eThe main function of recombinant mouse CHIT1 protein is the hydrolysis of chitin, which is found in the cell walls of fungi, insects, and crustaceans. It cleaves the beta-1,4-glycosidic bond between N-acetylglucosamine residues, releasing chitobiose as a product.\u003c\/p\u003e \u003cp\u003eStudies have shown that recombinant mouse CHIT1 protein has a higher activity towards chitin compared to other chitinases, making it a valuable tool for chitin degradation in various applications. It has also been found to have antifungal activity, inhibiting the growth of fungi by breaking down their cell walls.\u003c\/p\u003e \u003cp\u003eIn addition to its chitinase activity, recombinant mouse CHIT1 protein has been shown to have immunomodulatory effects. It can stimulate the production of pro-inflammatory cytokines and chemokines, as well as enhance the phagocytic activity of macrophages. This makes it a potential therapeutic target for immune-related diseases.\u003c\/p\u003e \u003ch2\u003eApplication of Recombinant Mouse CHIT1 Protein\u003c\/h2\u003e \u003cp\u003eRecombinant mouse CHIT1 protein has a wide range of applications in both research and industrial settings. Its chitinase activity makes it a valuable tool for the degradation of chitin in various industries, such as food, agriculture, and waste management.\u003c\/p\u003e \u003cp\u003eIn the research field, recombinant mouse CHIT1 protein is used to study the role of chitinases in various biological processes, such as fungal infections, immune responses, and insect development. It is also used in the production of chitobiose, which has potential applications in the pharmaceutical industry as a prebiotic and drug delivery agent.\u003c\/p\u003e \u003cp\u003eFurthermore, recombinant mouse CHIT1 protein has been investigated as a potential therapeutic agent for diseases such as asthma, inflammatory bowel disease, and cancer. Its immunomodulatory effects and ability to degrade chitin make it a promising candidate for the treatment of these conditions.\u003c\/p\u003e \u003ch2\u003eConclusion\u003c\/h2\u003e \u003cp\u003eIn summary, recombinant mouse CHIT1 protein is a versatile enzyme with a wide range of applications. Its structure, activity, and potential therapeutic properties make it a valuable tool in both research and industrial settings. Further studies on this protein will provide a better understanding of its role in various biological processes and may pave the way for new therapeutic interventions.\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number ARO-P11076. For research use only.\u003c\/p\u003e\u003cp\u003eHost: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 42.35 kDa; Fragment: Lys23-Leu383; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/ARO-P11076.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57358854717780,"sku":"ABM141513-1","price":188.0,"currency_code":"GBP","in_stock":true},{"title":"100ug","offer_id":57358854750548,"sku":"ABM141513-2","price":284.0,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":57358854783316,"sku":"ABM141513-3","price":772.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/3d-representation-image-recombinant-mouse-chit1-protein-n-his_85ac98a3-3560-4c41-ba0f-9ebb306a1ff8.webp?v=1790894064","url":"https:\/\/www.abmium.com\/products\/proteogenix-recombinant-mouse-chit1-protein-n-his","provider":"ABMIUM","version":"1.0","type":"link"}