{"product_id":"proteogenix-recombinant-mouse-cd226-dnam-1-protein-n-his","title":"Recombinant Mouse CD226\/DNAM-1 Protein, N-His","description":"\u003ch2\u003eIntroduction\u003c\/h2\u003e \u003cp\u003eRecombinant Mouse CD226\/DNAM-1 Protein is a genetically engineered protein that is derived from the mouse CD226 gene. This protein plays a crucial role in immune response and is involved in the regulation of T cell activation and cytotoxicity. In this article, we will discuss the structure, activity and applications of this recombinant protein.\u003c\/p\u003e \u003ch2\u003eStructure of Recombinant Mouse CD226\/DNAM-1 Protein\u003c\/h2\u003e \u003cp\u003eThe recombinant mouse CD226\/DNAM-1 protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is composed of a single extracellular domain, a transmembrane domain and a cytoplasmic tail. The extracellular domain consists of two immunoglobulin-like domains, an N-terminal V-type domain and a C-terminal C2-type domain. These domains are responsible for binding to ligands and interacting with other proteins.\u003c\/p\u003e \u003ch2\u003eActivity of Recombinant Mouse CD226\/DNAM-1 Protein\u003c\/h2\u003e \u003cp\u003eThe main function of CD226\/DNAM-1 protein is to regulate T cell activation and cytotoxicity. It acts as a co-stimulatory molecule on T cells and enhances their response to antigen stimulation. This protein also plays a crucial role in the activation of natural killer (NK) cells and promotes their cytotoxicity against target cells.\u003c\/p\u003e \u003cp\u003eCD226\/DNAM-1 protein has been shown to interact with multiple ligands, including CD155, CD112, and CD96. These interactions lead to the activation of downstream signaling pathways, such as the PI3K\/AKT and MAPK pathways, which are involved in T cell and NK cell activation.\u003c\/p\u003e \u003cp\u003eIn addition to its role in immune response, CD226\/DNAM-1 protein has also been implicated in the regulation of tumor growth and metastasis. It has been shown to promote the killing of tumor cells by NK cells and T cells, and its expression is often downregulated in various types of cancer.\u003c\/p\u003e \u003ch2\u003eApplications of Recombinant Mouse CD226\/DNAM-1 Protein\u003c\/h2\u003e \u003cp\u003eRecombinant Mouse CD226\/DNAM-1 Protein has a wide range of applications in both research and clinical settings. Here are some of the major applications of this protein:\u003c\/p\u003e \u003ch2\u003e1. Immunotherapy\u003c\/h2\u003e \u003cp\u003eCD226\/DNAM-1 protein has been identified as a potential target for cancer immunotherapy. By enhancing the activity of NK cells and T cells, this protein can help in the elimination of tumor cells. Recombinant CD226\/DNAM-1 protein can be used in combination with other immunotherapeutic agents to enhance their efficacy.\u003c\/p\u003e \u003ch2\u003e2. Vaccine development\u003c\/h2\u003e \u003cp\u003eThe ability of CD226\/DNAM-1 protein to enhance T cell response makes it a potential candidate for vaccine development. Recombinant CD226\/DNAM-1 protein can be used as an adjuvant to boost the immune response to vaccines.\u003c\/p\u003e \u003ch2\u003e3. Biomarker for cancer diagnosis and prognosis\u003c\/h2\u003e \u003cp\u003eThe expression of CD226\/DNAM-1 protein has been found to be altered in various types of cancer. As a result, it can serve as a potential biomarker for cancer diagnosis and prognosis. Recombinant CD226\/DNAM-1 protein can be used in diagnostic tests to detect the levels of this protein in patient samples.\u003c\/p\u003e \u003ch2\u003e4. Drug target for autoimmune diseases\u003c\/h2\u003e \u003cp\u003eCD226\/DNAM-1 protein has been implicated in the pathogenesis of several autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Recombinant CD226\/DNAM-1 protein can be used in drug discovery and development to identify potential inhibitors or modulators of this protein for the treatment of autoimmune diseases.\u003c\/p\u003e \u003ch2\u003eConclusion\u003c\/h2\u003e \u003cp\u003eIn summary, Recombinant Mouse CD226\/DNAM-1 Protein is a crucial protein involved in immune response and has various applications in research and clinical settings. Its structure, activity and applications make it a promising target for cancer immunotherapy, vaccine development, and as a biomarker for\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number ARO-P11075. For research use only.\u003c\/p\u003e\u003cp\u003eHost: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 28.20 kDa; Fragment: Thr26-Pro254; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/ARO-P11075.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57358855176532,"sku":"ABM141514-1","price":211.0,"currency_code":"USD","in_stock":true},{"title":"100ug","offer_id":57358855209300,"sku":"ABM141514-2","price":341.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":57358855242068,"sku":"ABM141514-3","price":917.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/3d-representation-image-recombinant-mouse-cd226-dnam-1-protein-n-his_ccf88409-f056-49da-9968-24f735bd36a2.webp?v=1790894065","url":"https:\/\/www.abmium.com\/products\/proteogenix-recombinant-mouse-cd226-dnam-1-protein-n-his","provider":"ABMIUM","version":"1.0","type":"link"}