{"product_id":"proteogenix-recombinant-human-otud1-protein-n-his","title":"Recombinant Human OTUD1 Protein, N-His","description":"\u003ch2\u003eIntroduction\u003c\/h2\u003e \u003cp\u003eRecombinant Human OTUD1 Protein is a highly purified and biologically active protein produced through recombinant DNA technology. It is a member of the ovarian tumor (OTU) domain-containing family of deubiquitinating enzymes and plays a crucial role in regulating the cellular ubiquitin pathway.\u003c\/p\u003e \u003ch2\u003eStructure of Recombinant Human OTUD1 Protein\u003c\/h2\u003e \u003cp\u003eRecombinant Human OTUD1 Protein is a 75 kDa protein consisting of 673 amino acids. It contains a conserved OTU domain at its N-terminus and a C-terminal ubiquitin-interacting motif (UIM). The OTU domain is responsible for the catalytic activity of the protein, while the UIM allows for specific binding to ubiquitin molecules.\u003c\/p\u003e \u003cp\u003eThe recombinant protein is produced in a mammalian expression system, ensuring proper folding and post-translational modifications. It is then purified using advanced chromatography techniques, resulting in a highly pure and active protein.\u003c\/p\u003e \u003ch2\u003eActivity of Recombinant Human OTUD1 Protein\u003c\/h2\u003e \u003cp\u003eRecombinant Human OTUD1 Protein is a deubiquitinating enzyme that specifically cleaves K48-linked polyubiquitin chains. It acts as a negative regulator of the ubiquitin-proteasome system, which is responsible for the degradation of damaged or unwanted proteins in the cell.\u003c\/p\u003e \u003cp\u003eOTUD1 exerts its activity by removing ubiquitin molecules from target proteins, thus preventing their degradation. This process is essential for maintaining proper protein homeostasis and preventing the accumulation of misfolded or damaged proteins, which can lead to various diseases.\u003c\/p\u003e \u003cp\u003eAdditionally, OTUD1 has been shown to play a role in DNA damage response and cell cycle regulation. It interacts with various proteins involved in these processes, such as BRCA1 and p53, and helps maintain genomic stability and prevent the development of cancer.\u003c\/p\u003e \u003ch2\u003eApplications of Recombinant Human OTUD1 Protein\u003c\/h2\u003e \u003cp\u003eRecombinant Human OTUD1 Protein has a wide range of applications in both research and therapeutic fields.\u003c\/p\u003e \u003ch2\u003eResearch Applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eStudying the role of OTUD1 in regulating the ubiquitin-proteasome system and its impact on protein homeostasis\u003c\/li\u003e \u003cli\u003eInvestigating the involvement of OTUD1 in DNA damage response and cell cycle regulation\u003c\/li\u003e \u003cli\u003eExamining the interaction of OTUD1 with other proteins and its role in various cellular processes\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eTherapeutic Applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eDeveloping OTUD1-targeted therapies for diseases caused by dysregulation of the ubiquitin-proteasome system, such as neurodegenerative diseases and cancer\u003c\/li\u003e \u003cli\u003eUsing OTUD1 as a biomarker for cancer diagnosis and prognosis\u003c\/li\u003e \u003cli\u003eExploring the potential of OTUD1 as a therapeutic target for diseases involving DNA damage and genomic instability\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eConclusion\u003c\/h2\u003e \u003cp\u003eRecombinant Human OTUD1 Protein is a crucial player in regulating the ubiquitin-proteasome system and maintaining proper protein homeostasis. Its unique structure and activity make it a valuable tool for studying cellular processes and developing targeted therapies for various diseases. With ongoing research, the potential of OTUD1 in both research and therapeutic fields continues to grow.\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number ARO-P10385. For research use only.\u003c\/p\u003e\u003cp\u003eHost: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 53.36 kDa; Fragment: Met1-Ser481; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/ARO-P10385.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57358733771092,"sku":"ABM140824-1","price":159.2,"currency_code":"GBP","in_stock":true},{"title":"100ug","offer_id":57358733803860,"sku":"ABM140824-2","price":207.2,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":57358733836628,"sku":"ABM140824-3","price":615.2,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/sds-validation-1-recombinant-human-otud1-protein-n-his_f9d86402-6721-4923-ad60-6be383ffa6e1.jpg?v=1790893588","url":"https:\/\/www.abmium.com\/products\/proteogenix-recombinant-human-otud1-protein-n-his","provider":"ABMIUM","version":"1.0","type":"link"}