{"product_id":"proteogenix-cd122-recombinant-protein","title":"CD122 Recombinant Protein","description":"\u003ch2\u003eGeneral information on CD122 Recombinant Protein:\u003c\/h2\u003e \u003cp\u003e The interleukin-2 receptor (IL-2R), also known as the β subunit receptor of the β subunit IL-2, subunit of the IL-2 β and IL-2RB receptor, participates in the immune response of T cells. ability to bind interleukin 2, CD122 \/ IL-2RB exists in three forms. The low affinity form is a monomer of the alpha subunit and does not participate in signal transmission. The intermediate affine form is composed of α \/ β subunit heterodimers, while the high affinity form is composed of α \/ β \/ gamma heterotrimers. Both forms of medium and high affinity for CD122 \/ IL-2RB are involved in receptor-mediated endocytosis and interleukin-2-mediated mitotic signal transduction. CD122 \/ IL-2RB expression is limited to older B22 + cells (CD43 + CD24- prepro B cells, fraction A), which can proliferate to IL-2 strongly without any stromal cells, but not to IL-15 A High affinity form of the receptor is expressed in activated T lymphocytes, activated B lymphocytes and activated macrophages. CD122 \/ IL-2RB plays a role in regulating normal lymphocyte development.\u003c\/p\u003e\u003cp\u003eProteoGenix catalogue number PX-P4103. For research use only.\u003c\/p\u003e\u003cp\u003eHost: Mammalian cells; Expression system: Eukaryotic expression; Purity: \u0026gt;90% by SDS-PAGE; Molecular weight: 35-45kDa; Tag: C-terminal His Tag; Fragment: Met1-Asp239; Buffer: PBS pH7.5; Applications: ELISA, WB.\u003c\/p\u003e\u003cp\u003eAvailable configurations: 50ug, 100ug, 1mg.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.proteogenix.science\/wp-content\/uploads\/documents\/Datasheets\/PX-P4103.pdf\"\u003eDownload the manufacturer datasheet\u003c\/a\u003e\u003c\/p\u003e","brand":"ProteoGenix","offers":[{"title":"50ug","offer_id":57376232866132,"sku":"ABM146410-1","price":151.2,"currency_code":"GBP","in_stock":true},{"title":"100ug","offer_id":57376232898900,"sku":"ABM146410-2","price":236.0,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":57376232931668,"sku":"ABM146410-3","price":676.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/3d-representation-image-cd122-recombinant-protein.webp?v=1790896792","url":"https:\/\/www.abmium.com\/products\/proteogenix-cd122-recombinant-protein","provider":"ABMIUM","version":"1.0","type":"link"}