{"product_id":"elk-es8433-p300-acetyl-lys1558-acetyl-lys1560-rabbit-pab","title":"p300 (Acetyl Lys1558\/Acetyl Lys1560) rabbit pAb","description":"\u003cp\u003ep300 (Acetyl Lys1558\/Acetyl Lys1560) rabbit pAb is an ELK Biotechnology antibody for research workflows involving p300.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eE1A binding protein p300(EP300) Homo sapiens This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eAcetyl-p300 (K1558\/K1560) Polyclonal Antibody detects endogenous levels of p300 around the acetylation site of K1558 protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern blot analysis of HELA 293T using Acetyl-p300 (K1558\/K1560) antibody. Antibody was diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187415953748,"sku":"ABM109654","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187415986516,"sku":"ABM99790","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES8433-c-1.jpg?v=1782054923","url":"https:\/\/www.abmium.com\/products\/elk-es8433-p300-acetyl-lys1558-acetyl-lys1560-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}