{"product_id":"elk-es8096-cleaved-cd97alpha-l530-rabbit-pab","title":"Cleaved-CD97α (L530) rabbit pAb","description":"\u003cp\u003eCleaved-CD97α (L530) rabbit pAb is an ELK Biotechnology antibody for research workflows involving CD97α.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 1\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eCleaved-CD97α (L530) Polyclonal Antibody detects endogenous levels of fragment of activated CD97α protein resulting from cleavage adjacent to L530.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern blot analysis of CD97alpha (Cleaved-Leu530) Antibody. The lane on the right is blocked with the CD97alpha (Cleaved-Leu530) peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187405697364,"sku":"ABM109592","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187405730132,"sku":"ABM99728","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES8096-c-1.jpg?v=1782054778","url":"https:\/\/www.abmium.com\/products\/elk-es8096-cleaved-cd97alpha-l530-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}