{"product_id":"elk-es7839-p63-phospho-ser395-rabbit-pab","title":"p63 (phospho Ser395) rabbit pAb","description":"\u003cp\u003ep63 (phospho Ser395) rabbit pAb is an ELK Biotechnology antibody for research workflows involving p40\/p63.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003etumor protein p63(TP63) Homo sapiens This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem\/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip\/palate syndrome 3 (EEC3); split-hand\/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip\/palate; ADULT syndrome (acro-dermato-ungual-lacrim\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-p63 (S395) Polyclonal Antibody detects endogenous levels of p63 protein only when phosphorylated at S395.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern blot analysis of lysates from LOVO cells treated with nocodazole 1ug\/ml 18h, A549 cells treated with nocodazole 1ug\/ml 18h and HepG2 cells treated with nocodazole 1ug\/ml 18h, using p63 (Phospho-Ser395) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187305984340,"sku":"ABM109488","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187306017108,"sku":"ABM99624","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES7839-c-1.jpg?v=1782052130","url":"https:\/\/www.abmium.com\/products\/elk-es7839-p63-phospho-ser395-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}