{"product_id":"elk-es7702-cleaved-caspase-4-5-p20-d270-d311-rabbit-pab","title":"Cleaved-Caspase-4\/5 p20 (D270\/D311) rabbit pAb","description":"\u003cp\u003eCleaved-Caspase-4\/5 p20 (D270\/D311) rabbit pAb is an ELK Biotechnology antibody for research workflows involving Caspase-4\/5.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eCleaved-Caspase-4\/5 p20 (D270\/D311) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-4\/5 p20 protein resulting from cleavage adjacent to D270\/D311.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern blot analysis of Caspase 4\/5 (p20, Cleaved-Asp270\/Asp311) Antibody. The lane on the right is blocked with the Caspase 4\/5 (p20, Cleaved-Asp270\/Asp311) peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187301757268,"sku":"ABM109436","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187301790036,"sku":"ABM99572","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES7702-c-1.jpg?v=1782051980","url":"https:\/\/www.abmium.com\/products\/elk-es7702-cleaved-caspase-4-5-p20-d270-d311-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}