{"product_id":"elk-es7699-caspase-3-phospho-ser150-rabbit-pab","title":"Caspase-3 (phospho Ser150) rabbit pAb","description":"\u003cp\u003eCaspase-3 (phospho Ser150) rabbit pAb is an ELK Biotechnology antibody for research workflows involving Caspase-3.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-Caspase-3 (S150) Polyclonal Antibody detects endogenous levels of Caspase-3 protein only when phosphorylated at S150.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern blot analysis of HBE using p-Caspase-3 (S150) antibody. Antibody was diluted at 1:1000 | Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Caspase 3 (Phospho-Ser150) Antibody | Immunohistochemistry analysis of paraffin-embedded human lymph node, using Caspase 3 (Phospho-Ser150) Antibody. The picture on the right is blocked with the phospho peptide. | Western blot analysis of lysates from Jurkat cells treated with Etoposide 25uM 60', using Caspase 3 (Phospho-Ser150) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187301691732,"sku":"ABM109435","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187301724500,"sku":"ABM99571","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES7699-c-1.jpg?v=1782051968","url":"https:\/\/www.abmium.com\/products\/elk-es7699-caspase-3-phospho-ser150-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}