{"product_id":"elk-es7586-tnf-ip-8l2-rabbit-pab","title":"TNF-IP 8L2 rabbit pAb","description":"\u003cp\u003eTNF-IP 8L2 rabbit pAb is an ELK Biotechnology antibody for research workflows involving TNF-IP 8L2.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003edomain:The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.,function:Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun\/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.,similarity:Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.,subunit:May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.,\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eTNF-IP 8L2 Polyclonal Antibody detects endogenous levels of TNF-IP 8L2 protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern blot analysis of the lysates from HeLa cells using TNFAIP8L2 antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187294187860,"sku":"ABM109389","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187294220628,"sku":"ABM99525","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES7586-c-1.jpg?v=1782051871","url":"https:\/\/www.abmium.com\/products\/elk-es7586-tnf-ip-8l2-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}