{"product_id":"elk-es6836-pkr-phospho-thr446-rabbit-pab","title":"PKR (phospho Thr446) rabbit pAb","description":"\u003cp\u003ePKR (phospho Thr446) rabbit pAb is an ELK Biotechnology antibody for research workflows involving PKR.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene is a serine\/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-PKR (T446) Polyclonal Antibody detects endogenous levels of PKR protein only when phosphorylated at T446.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eEnzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using PKR (Phospho-Thr446) Antibody | Western blot analysis of lysates from NIH\/3T3 cells treated with IFN 2500U\/ml 30', using PKR (Phospho-Thr446) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187251818836,"sku":"ABM109120","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187251851604,"sku":"ABM99256","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES6836-c-1.jpg?v=1782051250","url":"https:\/\/www.abmium.com\/products\/elk-es6836-pkr-phospho-thr446-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}