{"product_id":"elk-es6242-ciita-rabbit-pab","title":"CIITA rabbit pAb","description":"\u003cp\u003eCIITA rabbit pAb is an ELK Biotechnology antibody for research workflows involving CIITA.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eclass II major histocompatibility complex transactivator(CIITA) Homo sapiens This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the \"master control factor\" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardi\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eCIITA Polyclonal Antibody detects endogenous levels of CIITA protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern blot analysis of lysates from K562 cells, using CIITA Antibody. The lane on the right is blocked with the synthesized peptide. | Western Blot analysis of K562, Mouse-kidney,Rat-kidney, Primary Antibody was diluted at 1:1000. Secondary antibody(catalog#:RS0002 was diluted at 1:10000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187226325332,"sku":"ABM108915","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187226358100,"sku":"ABM99051","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES6242-c-1.jpg?v=1782050810","url":"https:\/\/www.abmium.com\/products\/elk-es6242-ciita-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}