{"product_id":"elk-es6004-kir3-1-phospho-ser185-rabbit-pab","title":"KIR3.1 (phospho Ser185) rabbit pAb","description":"\u003cp\u003eKIR3.1 (phospho Ser185) rabbit pAb is an ELK Biotechnology antibody for research workflows involving KIR3.1.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePotassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, at\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-KIR3.1 (S185) Polyclonal Antibody detects endogenous levels of KIR3.1 protein only when phosphorylated at S185.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eEnzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using GIRK1\/KIR3.1\/KCNJ3 (Phospho-Ser185) Antibody | Immunofluorescence analysis of HeLa cells, using GIRK1\/KIR3.1\/KCNJ3 (Phospho-Ser185) Antibody. The picture on the right is blocked with the phospho peptide. | Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using GIRK1\/KIR3.1\/KCNJ3 (Phospho-Ser185) Antibody. The picture on the right is blocked with the phospho peptide. | Western blot analysis of lysates from RAW264.7 cells treated with Insulin 0.01U\/ml 15', using GIRK1\/KIR3.1\/KCNJ3 (Phospho-Ser185) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187211317588,"sku":"ABM108813","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187211350356,"sku":"ABM98949","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES6004-c-1.jpg?v=1782050483","url":"https:\/\/www.abmium.com\/products\/elk-es6004-kir3-1-phospho-ser185-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}