{"product_id":"elk-es5957-integrin-beta4-phospho-tyr1510-rabbit-pab","title":"Integrin β4 (phospho Tyr1510) rabbit pAb","description":"\u003cp\u003eIntegrin β4 (phospho Tyr1510) rabbit pAb is an ELK Biotechnology antibody for research workflows involving Integrin β4.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eIntegrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-Integrin β4 (Y1510) Polyclonal Antibody detects endogenous levels of Integrin β4 protein only when phosphorylated at Y1510.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of AD293 using Phospho-Integrin β4 (Y1510) Polyclonal Antibody. Antibody was diluted at 1:500 | Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using ITGB4 (Phospho-Tyr1510) Antibody | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using ITGB4 (Phospho-Tyr1510) Antibody. The picture on the right is blocked with the phospho peptide. | Western blot analysis of lysates from HepG2 cells treated with Na2VO3 0.3nM 40', using ITGB4 (Phospho-Tyr1510) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187208106324,"sku":"ABM108797","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187208139092,"sku":"ABM98933","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES5957-c-1.jpg?v=1782050723","url":"https:\/\/www.abmium.com\/products\/elk-es5957-integrin-beta4-phospho-tyr1510-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}