{"product_id":"elk-es5873-il-2rbeta-phospho-tyr364-rabbit-pab","title":"IL-2Rβ (phospho Tyr364) rabbit pAb","description":"\u003cp\u003eIL-2Rβ (phospho Tyr364) rabbit pAb is an ELK Biotechnology antibody for research workflows involving IL-2Rβ.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha\/beta subunit heterodimer, while the high affinity form consists of an alpha\/beta\/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an up\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-IL-2Rβ (Y364) Polyclonal Antibody detects endogenous levels of IL-2Rβ protein only when phosphorylated at Y364.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of 293T cells using Phospho-IL-2Rβ (Y364) Polyclonal Antibody diluted at 1:500 | Western blot analysis of lysates from COS7 cells, using IL-2R beta\/CD122 (Phospho-Tyr364) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187203977556,"sku":"ABM108766","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187204010324,"sku":"ABM98902","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES5873-c-1.jpg?v=1782050369","url":"https:\/\/www.abmium.com\/products\/elk-es5873-il-2rbeta-phospho-tyr364-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}