{"product_id":"elk-es5692-blnk-phospho-tyr96-rabbit-pab","title":"BLNK (phospho Tyr96) rabbit pAb","description":"\u003cp\u003eBLNK (phospho Tyr96) rabbit pAb is an ELK Biotechnology antibody for research workflows involving BLNK.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-BLNK (Y96) Polyclonal Antibody detects endogenous levels of BLNK protein only when phosphorylated at Y96.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of COLO205 cells using Phospho-BLNK (Y96) Polyclonal Antibody | Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using BLNK (Phospho-Tyr96) Antibody | Immunohistochemistry analysis of paraffin-embedded human lymph node, using BLNK (Phospho-Tyr96) Antibody. The picture on the right is blocked with the phospho peptide. | Western blot analysis of lysates from COLO205 cells, using BLNK (Phospho-Tyr96) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187191984468,"sku":"ABM108689","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187192017236,"sku":"ABM98825","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES5692-c-1.jpg?v=1782050199","url":"https:\/\/www.abmium.com\/products\/elk-es5692-blnk-phospho-tyr96-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}