{"product_id":"elk-es5668-grf-1-phospho-tyr1087-rabbit-pab","title":"GRF-1 (phospho Tyr1087) rabbit pAb","description":"\u003cp\u003eGRF-1 (phospho Tyr1087) rabbit pAb is an ELK Biotechnology antibody for research workflows involving GRF-1.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-GRF-1 (Y1087) Polyclonal Antibody detects endogenous levels of GRF-1 protein only when phosphorylated at Y1087.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of 293T cells using Phospho-GRF-1 (Y1087) Polyclonal Antibody diluted at 1:1000 | Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using GRF-1 (Phospho-Tyr1087) Antibody | Western blot analysis of lysates from K562 cells, using phospho-GRF-1 (Phospho-Tyr1087) antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56187191329108,"sku":"ABM108682","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56187191361876,"sku":"ABM98818","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES5668-c-1.jpg?v=1782050359","url":"https:\/\/www.abmium.com\/products\/elk-es5668-grf-1-phospho-tyr1087-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}