{"product_id":"elk-es4932-grk-2-phospho-ser685-rabbit-pab","title":"GRK 2 (phospho Ser685) rabbit pAb","description":"\u003cp\u003eGRK 2 (phospho Ser685) rabbit pAb is an ELK Biotechnology antibody for research workflows involving GRK 2.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-GRK 2 (S685) Polyclonal Antibody detects endogenous levels of GRK 2 protein only when phosphorylated at S685.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of JK cells using Phospho-GRK 2 (S685) Polyclonal Antibody diluted at 1:500 | Western blot analysis of lysates from HT29 cells treated with insulin 0.01U\/ml 15', using GRK2 (Phospho-Ser685) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56186792345940,"sku":"ABM108364","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56186792378708,"sku":"ABM98500","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES4932-c-1.jpg?v=1782047840","url":"https:\/\/www.abmium.com\/products\/elk-es4932-grk-2-phospho-ser685-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}