{"product_id":"elk-es4591-chk1-phospho-ser280-rabbit-pab","title":"Chk1 (phospho Ser280) rabbit pAb","description":"\u003cp\u003eChk1 (phospho Ser280) rabbit pAb is an ELK Biotechnology antibody for research workflows involving Chk1.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene belongs to the Ser\/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-Chk1 (S280) Polyclonal Antibody detects endogenous levels of Chk1 protein only when phosphorylated at S280.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of 293T cells using Phospho-Chk1 (S280) Polyclonal Antibody diluted at 1:500 | Western blot analysis of lysates from HeLa cells treated with Hu 2nM 24hours, using Chk1 (Phospho-Ser280) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56186709705044,"sku":"ABM108213","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56186709737812,"sku":"ABM98349","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES4591-c-1.jpg?v=1782047487","url":"https:\/\/www.abmium.com\/products\/elk-es4591-chk1-phospho-ser280-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}