{"product_id":"elk-es4389-troponin-i-c-phospho-ser22-s23-rabbit-pab","title":"Troponin I-C (phospho Ser22\/S23) rabbit pAb","description":"\u003cp\u003eTroponin I-C (phospho Ser22\/S23) rabbit pAb is an ELK Biotechnology antibody for research workflows involving Troponin I-C.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eTroponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: tnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-Troponin I-C (S22\/S23) Polyclonal Antibody detects endogenous levels of Troponin I-C protein only when phosphorylated at S22\/S23.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of SH-SY5Y cells using Phospho-Troponin I-C (S22\/S23) Polyclonal Antibody diluted at 1:1000 | Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using TNNI3 (Phospho-Ser22+Ser23) Antibody | Immunohistochemistry analysis of paraffin-embedded human skeletal muscle, using TNNI3 (Phospho-Ser22+Ser23) Antibody. The picture on the right is blocked with the phospho peptide. | Western blot analysis of lysates from mouse heart, using TNNI3 (Phospho-Ser22+Ser23) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56186699678036,"sku":"ABM108116","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56186699710804,"sku":"ABM98252","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES4389-c-1.jpg?v=1782047269","url":"https:\/\/www.abmium.com\/products\/elk-es4389-troponin-i-c-phospho-ser22-s23-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}