{"product_id":"elk-es4388-na-plus-k-plus-atpase-alpha1-phospho-ser23-rabbit-pab","title":"Na+\/K+-ATPase α1 (phospho Ser23) rabbit pAb","description":"\u003cp\u003eNa+\/K+-ATPase α1 (phospho Ser23) rabbit pAb is an ELK Biotechnology antibody for research workflows involving Na+\/K+-ATPase α1.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe ATPase Na+\/K+ transporting subunit alpha 1 encoded by ATP1A1 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+\/K+ -ATPases. Na+\/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+\/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-Na+\/K+-ATPase α1 (S23) Polyclonal Antibody detects endogenous levels of Na+\/K+-ATPase α1 protein only when phosphorylated at S23.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of rat cells using Phospho-Na+\/K+-ATPase α1 (S23) Polyclonal Antibody | Immunofluorescence analysis of NIH\/3T3 cells, using ATP1 alpha1\/Na+K+ ATPase1 (Phospho-Ser23) Antibody. The picture on the right is blocked with the phospho peptide. | Western blot analysis of lysates from rat brain, using ATP1 alpha1\/Na+K+ ATPase1 (Phospho-Ser23) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56186699612500,"sku":"ABM108115","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56186699645268,"sku":"ABM98251","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES4388-c-1.jpg?v=1782047268","url":"https:\/\/www.abmium.com\/products\/elk-es4388-na-plus-k-plus-atpase-alpha1-phospho-ser23-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}