{"product_id":"elk-es3621-tnf-ip-8-rabbit-pab","title":"TNF-IP 8 rabbit pAb","description":"\u003cp\u003eTNF-IP 8 rabbit pAb is an ELK Biotechnology antibody for research workflows involving TNF-IP 8.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003edevelopmental stage:Expressed at high levels in the fetal liver, lung and kidney.,function:Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.,induction:By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.,similarity:Belongs to the TNFAIP8 family.,tissue specificity:Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.,\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eTNF-IP 8 Polyclonal Antibody detects endogenous levels of TNF-IP 8 protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using TNF-IP 8 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000 | Immunofluorescence analysis of A549 cells, using TFIP8 Antibody. The picture on the right is blocked with the synthesized peptide. | Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TFIP8 Antibody. The picture on the right is blocked with the synthesized peptide. | Western blot analysis of lysates from HUVEC cells, using TFIP8 Antibody. The lane on the right is blocked with the synthesized peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56186599702868,"sku":"ABM107588","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56186599735636,"sku":"ABM97724","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES3621-c-1.jpg?v=1782045999","url":"https:\/\/www.abmium.com\/products\/elk-es3621-tnf-ip-8-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}