{"product_id":"elk-es3210-pinin-rabbit-pab","title":"Pinin rabbit pAb","description":"\u003cp\u003ePinin rabbit pAb is an ELK Biotechnology antibody for research workflows involving Pinin.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003efunction:Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Also participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the pinin family.,subcellular location:Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.,subunit:Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Interacts with C6orf111\/SRRP130, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D\/PNO40, PPIG, RNPS1, SFRS4 and SRRM2.\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePinin Polyclonal Antibody detects endogenous levels of Pinin protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Pinin Polyclonal Antibody | Western blot analysis of lysates from HT-29 cells, using PNN Antibody. The lane on the right is blocked with the synthesized peptide. | Western blot analysis of the lysates from K562 cells using PNN antibody. | Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56186531873108,"sku":"ABM107431","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56186531905876,"sku":"ABM97567","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES3210-c-1.jpg?v=1782045632","url":"https:\/\/www.abmium.com\/products\/elk-es3210-pinin-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}