{"product_id":"elk-es2886-n-h-k-ras-rabbit-pab","title":"N\/H\/K-Ras rabbit pAb","description":"\u003cp\u003eN\/H\/K-Ras rabbit pAb is an ELK Biotechnology antibody for research workflows involving N\/H\/K-Ras.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eN\/H\/K-Ras Polyclonal Antibody detects endogenous levels of N\/H\/K-Ras protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eImmunofluorescence analysis of A549. 1,primary Antibody(red) was diluted at 1:200(4°C overnight). 2, Goat Anti Rabbit IgG (H\u0026amp;L) - Alexa Fluor 594 Secondary antibody was diluted at 1:1000(room temperature, 50min).3, Picture B: DAPI(blue) 10min. | Western Blot analysis of various cells using N\/H\/K-Ras Polyclonal Antibody diluted at 1:1000 | Western Blot analysis of 293 cells using N\/H\/K-Ras Polyclonal Antibody diluted at 1:1000 | Immunohistochemistry analysis of paraffin-embedded human brain tissue, using RASH\/RASK Antibody. The picture on the right is blocked with the synthesized peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56186203537748,"sku":"ABM107298","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56186203570516,"sku":"ABM97434","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES2886-c-1.jpg?v=1782043952","url":"https:\/\/www.abmium.com\/products\/elk-es2886-n-h-k-ras-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}