{"product_id":"elk-es2661-jmy-rabbit-pab","title":"JMY rabbit pAb","description":"\u003cp\u003eJMY rabbit pAb is an ELK Biotechnology antibody for research workflows involving JMY.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003efunction:Cofactor that increases p53\/TP53 response via its interaction with p300\/EP300. Increases p53\/TP53-dependent transcription and apoptosis, suggesting an important role in p53\/TP53 stress response such as DNA damage.,induction:By E2F.,PTM:Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300\/EP300 and its function in p53\/TP53 stress response.,similarity:Contains 1 WH2 domain.,subunit:Interacts with p300\/EP300, the complex being recruited to activated p53\/TP53. Interacts with TTC5.,\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eJMY Polyclonal Antibody detects endogenous levels of JMY protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using JMY Polyclonal Antibody | Western blot analysis of lysates from COLO cells, using JMY Antibody. The lane on the right is blocked with the synthesized peptide. | Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56186191380820,"sku":"ABM107199","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56186191413588,"sku":"ABM97335","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES2661-c-1.jpg?v=1782043712","url":"https:\/\/www.abmium.com\/products\/elk-es2661-jmy-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}