{"product_id":"elk-es2537-hla-dobeta-rabbit-pab","title":"HLA-DOβ rabbit pAb","description":"\u003cp\u003eHLA-DOβ rabbit pAb is an ELK Biotechnology antibody for research workflows involving HLA-DOβ.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eHLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eHLA-DOβ Polyclonal Antibody detects endogenous levels of HLA-DOβ protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using HLA-DOβ Polyclonal Antibody diluted at 1:1000 | Western blot analysis of HLA-DOB Antibody. The lane on the right is blocked with the HLA-DOB peptide. | Western blot analysis of the lysates from HeLa cells using HLA-DOB antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56186183549268,"sku":"ABM107141","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56186183582036,"sku":"ABM97277","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES2537-c-1.jpg?v=1782043630","url":"https:\/\/www.abmium.com\/products\/elk-es2537-hla-dobeta-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}