{"product_id":"elk-es1676-apc5-rabbit-pab","title":"APC5 rabbit pAb","description":"\u003cp\u003eAPC5 rabbit pAb is an ELK Biotechnology antibody for research workflows involving APC5.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex\/cyclosome (APC\/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC\/C and for the interaction of APC\/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eAPC5 Polyclonal Antibody detects endogenous levels of APC5 protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using APC5 Polyclonal Antibody | Western blot analysis of the lysates from HeLa cells using ANAPC5 antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56185684885844,"sku":"ABM105948","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56185684918612,"sku":"ABM96084","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1676-c-1.jpg?v=1782037707","url":"https:\/\/www.abmium.com\/products\/elk-es1676-apc5-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}