{"product_id":"elk-es1538-epor-phospho-tyr426-rabbit-pab","title":"EpoR (phospho Tyr426) rabbit pAb","description":"\u003cp\u003eEpoR (phospho Tyr426) rabbit pAb is an ELK Biotechnology antibody for research workflows involving EpoR.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras\/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-EpoR (Y426) Polyclonal Antibody detects endogenous levels of EpoR protein only when phosphorylated at Y426.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of extracts from K562 cells, using Phospho-EpoR (Y426) Polyclonal Antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56185615778132,"sku":"ABM105426","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56185615810900,"sku":"ABM95562","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1538-c-1.jpg?v=1782036308","url":"https:\/\/www.abmium.com\/products\/elk-es1538-epor-phospho-tyr426-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}