{"product_id":"elk-es14942-mkk7-phospho-ser271-thr275-rabbit-pab","title":"MKK7 (phospho-Ser271\/Thr275) rabbit pAb","description":"\u003cp\u003eMKK7 (phospho-Ser271\/Thr275) rabbit pAb is an ELK Biotechnology antibody for research workflows involving MKK7.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8\/JNK1 and MAPK9\/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1\/MEKK1, MAP3K2\/MEKK2,MAP3K3\/MEKK5, and MAP4K2\/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eThis antibody detects endogenous levels of Human MKK7 (phospho-Ser271 or Thr275)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night | Immunohistochemical analysis of paraffin-embedded human oophoroma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56185565282644,"sku":"ABM105151","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56185565315412,"sku":"ABM95287","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES14942-c-1.jpg?v=1782035613","url":"https:\/\/www.abmium.com\/products\/elk-es14942-mkk7-phospho-ser271-thr275-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}