{"product_id":"elk-es1378-p27-phospho-ser10-rabbit-pab","title":"p27 (phospho Ser10) rabbit pAb","description":"\u003cp\u003ep27 (phospho Ser10) rabbit pAb is an ELK Biotechnology antibody for research workflows involving p27.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A\/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-p27 (S10) Polyclonal Antibody detects endogenous levels of p27 protein only when phosphorylated at S10.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Phospho-p27 (S10) Polyclonal Antibody | Western blot analysis of lysates from A2780 and COLO205 cells, using p27 Kip1 (Phospho-Ser10) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56185416286548,"sku":"ABM104634","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56185416319316,"sku":"ABM94770","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1378-c-1.jpg?v=1782034813","url":"https:\/\/www.abmium.com\/products\/elk-es1378-p27-phospho-ser10-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}